Traumatic brain injury altered normal brain signaling pathways: implications for novel therapeutics approaches

A Rana, S Singh, R Sharma… - Current …, 2019 - benthamdirect.com
Traumatic brain injury (TBI) is the main reason of lifelong disability and casualty worldwide.
In the United State alone, 1.7 million traumatic events occur yearly, out of which 50,000 …

[HTML][HTML] Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

S Miwa, R Czapiewski, T Wan, A Bell, KN Hill… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Telomerase in its canonical function maintains telomeres in dividing cells. In addition, the
telomerase protein TERT has non-telomeric functions such as shuttling to mitochondria …

mTOR inhibition in primary neurons and the develo** brain represses transcription of cholesterol biosynthesis genes and alters cholesterol levels

M Schüle, T Butto, S Dewi, S Strand, S Gerber… - bioRxiv, 2020 - biorxiv.org
Dysregulated mammalian target of rapamycin (mTOR) activity is associated with various
neurodevelopmental disorders ranging from idiopathic autism spectrum disorders to …

[PDF][PDF] mTOR inhibition represses transcription of cholesterol biosynthesis genes and alters cholesterol levels in primary neurons and in the develo** brain

M Schüle, T Butto, S Dewi, S Strand, S Gerber… - scholar.archive.org
Dysregulated mammalian target of rapamycin (mTOR) activity is associated with various
neurodevelopmental disorders ranging from idiopathic autism spectrum disorders to …