Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-
inflammatory to reparative responses, and the cardiac fibroblast is a central player during …

The inappropriate deposition of extracellular matrix within the heart (termed cardiac fibrosis)
is associated with nearly all types of heart disease, including ischemic, hypertensive …

Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

Myocardial ischemia and infarction, both in the acute and chronic phases, are associated
with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (ECM). It …

Fibroblasts are the primary regulator of cardiac extracellular matrix (ECM). In response to
disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast …

Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Incidence and prevalence of cancer is an alarming situation globally. For the treatment of
cancer many anticancer drugs have been developed but, unfortunately, their potential …

Fibrosis, characterized by an excessive accumulation of extracellular matrix, has long been
seen as an adaptive process that contributes to tissue healing and regeneration. More …

Excessive scar formation is a hallmark of localized and systemic fibrotic disorders. Despite
extensive studies to define valid anti-fibrotic targets and develop effective therapeutics …