To provide a T-cell population that will respond promptly to foreign antigen, the immune
system looks inward, using the variety of self-antigens to select and maintain a diverse …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

We have used organ culture of fetal thymic lobes from T cell receptor (TCR) transgenic j? &f (-
I-) mice to study the role of peptides in positive selection. The TCR used was from a CD8+ T …

Comparative genomic hybridization produces a map of DNA sequence copy number as a
function of chromosomal location throughout the entire genome. Differentially labeled test …

The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens
in the thymus during maturation and then discriminate between foreign pathogens in the …

A host's ability to resist certain pathogens such as Leishmania major can depend upon the
phenotype of T helper (Th) subset that develops. Different murine genetic backgrounds are …

Differentiation of αβ T cell receptor (TCR)-expressing T cells involves an obligatory
interaction with self-major histocompatibility complex (MHC) molecules in the thymus. This …

Positive and negative selection of a iymphocytic choriomeningitis ViNS (LCMV) peptide-
Specifk, K2Dbrestricted T cell clone (P14) was studied using TAP1-and TAP1+ mice …

▪ Abstract Advances in gene technology have allowed the manipulation of molecular
interactions that shape the T cell repertoire. Although recognized as fundamental aspects of …

Simplistically, one may view the immune system as a war machine consisting of numerous
lymphocytes, each with a. specific surface receptor for antigen, designed to protect the …