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Breaking the barriers: The role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)
ABSTRACT Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in
Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic …
Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic …
The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …
of the most global problematic metabolic diseases with rapidly increasing prevalence and …
PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein
The I148M variant of PNPLA3 is closely associated with hepatic steatosis. Recent evidence
indicates that the I148M mutant functions as an inhibitor of PNPLA2/ATGL-mediated …
indicates that the I148M mutant functions as an inhibitor of PNPLA2/ATGL-mediated …
[HTML][HTML] Beneficial effects of betaine: a comprehensive review
Medicinal herbs and many food ingredients possess favorable biological properties that
contribute to their therapeutic activities. One such natural product is betaine, a stable …
contribute to their therapeutic activities. One such natural product is betaine, a stable …
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …
[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans
Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …
Triggering and resolution of inflammation in NASH
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …
Triglyceride metabolism in the liver
Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …
High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms
CY Lian, ZZ Zhai, ZF Li, L Wang - Chemico-biological interactions, 2020 - Elsevier
Obesity is characterized by the deposition of excessive body fat, and is caused by energy
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …
Lipid droplets and liver disease: from basic biology to clinical implications
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …