Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic
reprogramming plays a critical role in the activation of these bone cells and skeletal …

The field of bone repair and regeneration has undergone significant advancements, yet
challenges persist in achieving optimal bone implants or scaffolds, particularly load-bearing …

Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a
role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this …

There is mounting evidence of an association between osteoporosis and cardiovascular
disease that extends beyond shared risk factors for these conditions. In turn, the medications …

Background Combining mouse experiments with big data analysis of the Austrian
population, we investigated the association between high-dose statin treatment and bone …

One of the most ambitious goals for bone implants is to improve bioactivity, incapability, and
mechanical properties; to reduce the need for further surgery; and increase efficiency …

Purpose Statins are commonly prescribed medications with recognised side effects
including muscle weakness. Despite this, little is known about their effect on the physical …

Osteoclasts (OCs), which are responsible for bone resorption, play a critical role in
cholesterol-induced bone loss and recent studies have suggested that various micro-RNAs …

Hyperactivation of osteoclasts has been identified as a significant etiological factor in
several bone resorption-related disorders, including osteoporosis, periodontitis, arthritis, and …

Introduction Osteoporosis (OP) is a prevalent skeletal disease with high mortality and
morbidity, followed by acute and chronic back pain, severe spinal deformity and dysfunction …