The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
has caused more than 1 million deaths in the first 6 months of the pandemic and huge …

The year the issues in this report, Improving Representation in Clinical Tri als and Research,
became urgent for me was 2017. I was then chair of the US Preventive Services Task Force …

Chronic neurological diseases are the leading cause of disability globally. Yet, our health-
care systems are not designed to meet the needs of many patients with chronic neurological …

Background Older people are often explicitly or implicitly excluded from research, in
particular clinical trials. This means that study findings may not be applicable to them, or that …

Background Participants in clinical research studies often do not reflect the populations for
which healthcare interventions are needed or will be used. Enhancing representation of …

Background: currently one of the major challenges facing clinical guidelines is
multimorbidity. Current guidelines are not designed to consider the cumulative impact of …

Ageing is associated with several changes in human organs, which result in altered
medication pharmacokinetics and pharmacodynamics. Ageing is also associated with …

Objectives To establish the evidence for rehabilitation interventions tested in populations of
patients admitted to ICU and critical care with severe respiratory illness, and consider …

Background The aim of this review is to describe the challenges and barriers to conducting
research in long-term care facilities. Methods A literature search was conducted in Ovid …

Background This systematic review aimed to identify facilitators, barriers and strategies for
engaging 'hard to reach'older people in research on health promotion; the oldest old (≥ 80 …