Bioorthogonal chemistry for prodrug activation in vivo

Q Fu, S Shen, P Sun, Z Gu, Y Bai, X Wang… - Chemical Society …, 2023 - pubs.rsc.org
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Poly (glycerol)-based biomedical nanodevices constructed by functional programming on inorganic nanoparticles for cancer nanomedicine

N Komatsu - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Nanomedicine is promising to improve conventional cancer medicine by
making diagnosis and therapy more accurate and more effective in a more personalized …

Optimizing boron neutron capture therapy (BNCT) to treat cancer: an updated review on the latest developments on boron compounds and strategies

A Monti Hughes, N Hu - Cancers, 2023 - mdpi.com
Simple Summary Boron neutron capture therapy (BNCT) is a tumor-selective particle
radiotherapy. It combines preferential boron accumulation in tumors and neutron irradiation …

The dawn of a new era: tumor-targeting boron agents for neutron capture therapy

T Luo, W Huang, F Chu, T Zhu, B Feng… - Molecular …, 2023 - ACS Publications
Cancer is widely recognized as one of the most devastating diseases, necessitating the
development of intelligent diagnostic techniques, targeted treatments, and early prognosis …

Tumor Eradication by Boron Neutron Capture Therapy with 10B‐enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)

Y Zhang, HG Kang, H Xu, H Luo, M Suzuki… - Advanced …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high
precision and efficacy of intractable tumors. At the core of effective tumor BNCT are 10B …

BPA‐Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model

L Dai, J Liu, X Zhao, Y Li, S Zhou… - Advanced Functional …, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT) is a promising therapy for refractory cancer based on
the cytotoxic reaction of 10B (n, α) 7Li. Although two BNCT agents are clinically available …

Enhanced boron neutron capture therapy (BNCT) through controlled drug release via boron-loaded nanofiber mats

W Huang, Y Yang, Y Pan, S **g, Y Qi, Y Huang - Nano Research, 2024 - Springer
Boron neutron capture therapy (BNCT) is a novel binary therapy combining boron targeted
drugs and neutron irradiation, which can selectively and effectively kill cancer cells at the …

Rational Design, Multistep Synthesis and in Vitro Evaluation of Poly(glycerol) Functionalized Nanodiamond Conjugated with Boron‐10 Cluster and Active Targeting …

M Nishikawa, J Yu, HG Kang, M Suzuki… - … –A European Journal, 2023 - Wiley Online Library
Boron neutron capture therapy (BNCT), advanced cancer treatment utilizing nuclear fission
of 10B atom in cancer cells, is attracting increasing attention. As 10B delivery agent, sodium …

Rodlike nanomaterials from organic diradicaloid with high photothermal conversion capability for tumor treatment

T Sun, J Guo, H Wen, Q Pei, Q Wu, D Hao, C Dou… - …, 2023 - Wiley Online Library
Organic diradicaloids with unique open‐shell structures and properties have been widely
used in organic electronics and spintronics. However, their advantageous optical properties …

Recent Development of Radiofluorination of Boron Agents for Boron Neutron Capture Therapy of Tumor: Creation of 18F-Labeled CF and BF Linkages

JP Deng, CS Yu - Pharmaceuticals, 2023 - mdpi.com
Boron neutron capture therapy (BNCT) is a binary therapeutic technique employing a boron
agent to be delivered to the tumor site followed by the irradiation of neutrons. Biofunctional …