Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

Peroxisome proliferator–activated receptors (PPARs) regulate energy metabolism and
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …

Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …

With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is
now the most common cause of chronic liver disease in Western countries and its worldwide …

Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor
alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first …

Background Lymph node metastasis is one of most common determinants of the stage and
prognosis of gastric cancer (GC). However, the key molecular events and mechanisms …

Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. HCC incidence
is on the rise, while treatment options remain limited. Thus, a better understanding of the …

Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated
transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master …

The transcription factor FOSL1 plays an important role in cell differentiation and
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …