Enteric viruses replicate in salivary glands and infect through saliva
Enteric viruses like norovirus, rotavirus and astrovirus have long been accepted as
spreading in the population through fecal–oral transmission: viruses are shed into feces …
spreading in the population through fecal–oral transmission: viruses are shed into feces …
Neuroepithelial interactions in cancer
G Ayala - Annual Review of Pathology: Mechanisms of Disease, 2023 - annualreviews.org
Nerves not only regulate the homeostasis and energetic metabolism of normal epithelial
cells but also are critical for cancer, as cancer recapitulates the biology of neural regulation …
cells but also are critical for cancer, as cancer recapitulates the biology of neural regulation …
Trends in salivary gland tissue engineering: from stem cells to secretome and organoid bioprinting
Xerostomia or dry mouth are commonly diagnosed in head and neck cancer patients due to
salivary gland (SG) epithelial injury after radiotherapy. Regenerative medicine has fetched …
salivary gland (SG) epithelial injury after radiotherapy. Regenerative medicine has fetched …
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive.
Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin …
Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin …
Development of a functional salivary gland tissue chip with potential for high-content drug screening
Radiation therapy for head and neck cancers causes salivary gland dysfunction leading to
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …
permanent xerostomia. Limited progress in the discovery of new therapeutic strategies is …
Slow hydrogel matrix degradation enhances salivary gland mimetic phenotype
We recently developed a salivary gland tissue mimetic (SGm), comprised of salivary gland
cells encapsulated in matrix metalloproteinase (MMP)–degradable poly (ethylene glycol) …
cells encapsulated in matrix metalloproteinase (MMP)–degradable poly (ethylene glycol) …
CERE-120 prevents irradiation-induced hypofunction and restores immune homeostasis in porcine salivary glands
IMA Lombaert, VN Patel, CE Jones, DC Villier… - … Therapy-Methods & …, 2020 - cell.com
Salivary gland hypofunction causes significant morbidity and loss of quality of life for head
and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet …
and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet …
RGDSP-decorated hyaluronate hydrogels facilitate rapid 3D expansion of amylase-expressing salivary gland progenitor cells
EW Fowler, A Ravikrishnan, RL Witt… - ACS biomaterials …, 2021 - ACS Publications
In vitro engineering of salivary glands relies on the availability of synthetic matrices
presenting essential cell-instructive signals to guide tissue growth. Here, we describe a …
presenting essential cell-instructive signals to guide tissue growth. Here, we describe a …
Tissue engineered neurovascularization strategies for craniofacial tissue regeneration
Craniofacial tissue injuries, diseases, and defects, including those within bone, dental, and
periodontal tissues and salivary glands, impact an estimated 1 billion patients globally …
periodontal tissues and salivary glands, impact an estimated 1 billion patients globally …
Salivary gland tissue engineering approaches: state of the art and future directions
Salivary gland regeneration is important for develo** treatments for radiation-induced
xerostomia, Sjögren's syndrome, and other conditions that cause dry mouth. Culture …
xerostomia, Sjögren's syndrome, and other conditions that cause dry mouth. Culture …