Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens. Studies of …

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75
neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of …

Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells
has been the subject of numerous studies. Administration of exogenous neurotrophic factors …

Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …

Brown fat is highly active in fuel oxidation and dissipates chemical energy through
uncoupling protein (UCP) 1-mediated heat production. Activation of brown fat leads to …

To determine whether the p75 neurotrophin receptor (p75NTR) plays a role in naturally
occurring neuronal death, we examined neonatal sympathetic neurons that express both the …

Adiponectin, an adipokine secreted by the white adipose tissue, plays an important role in
regulating glucose and lipid metabolism and controlling energy homeostasis in insulin …

To determine how signals emanating from Trk transmit neurotrophin actions in primary
neurons, we tested the ability of TrkB mutated at defined effector binding sites to promote …

The neurotrophins signal cell survival, differentiation, growth cessation, and apoptosis
through two cell surface receptors, the Trks and p75NTR (p75 neurotrophin receptor) …