Generating inhibitors for AD isintegrin A nd M etalloproteinase 10 (ADAM10), a zinc-
dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 …

The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

Background Antibody-drug conjugates (ADC) are essential therapeutic options to treat solid
and hematological cancers. The anti-epidermal growth factor-receptor (EGFR) antibody …

Classic Hodgkin lymphoma (cHL) is characterized by a few tumor cells surrounded by a
protective, immunosuppressive tumor microenvironment composed of normal cells that are …

Mesenchymal stem cells (MSCs) are the most exploited stem cells with multilineage
differentiation potential and immunomodulatory properties. Numerous lines of findings have …

Alzheimer's disease (AD) involves complex pathological mechanisms. Secretases include
membrane protein extracellular structural domain proteases and intramembrane proteases …

Small extracellular vesicles (EVs) are a heterogenous group of lipid particles released by all
cell types in physiological and pathological states. In hematological malignancies, tumor …

At present, the treatment of lymphoma has entered the era of precision medicine, and CD30,
as a transmembrane protein, has become an important marker to help the diagnosis and …

NKG2D is an activating receptor expressed by NK cells and some subsets of T cells and
represents a major recognition receptor for detection and elimination of cancer cells. The …

Chemotherapy-induced senescence promotes immunocyte aggregation in the tumor
microenvironment by upregulating the surface expression of activating ligands in cancer …