Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms

AF Khan, Y Iturria-Medina - Translational Psychiatry, 2024 - nature.com
From Alzheimer's disease to amyotrophic lateral sclerosis, the molecular cascades
underlying neurodegenerative disorders remain poorly understood. The clinical view of …

A Multiform Heterogeneity Framework for Alzheimer's Disease Based on Multimodal Neuroimaging

K Zhao, P Chen, D Wang, R Zhou, G Ma, Y Liu - Biological Psychiatry, 2024 - Elsevier
Understanding the heterogeneity of Alzheimer's disease (AD) is crucial for advancing
precision medicine specifically tailored to this disorder. Recent research has deepened our …

Definition and analysis of gray matter atrophy subtypes in mild cognitive impairment based on data-driven methods

B Zhang, M Xu, Q Wu, S Ye, Y Zhang, Z Li… - Frontiers in Aging …, 2024 - frontiersin.org
Introduction Mild cognitive impairment (MCI) is an important stage in Alzheimer's disease
(AD) research, focusing on early pathogenic factors and mechanisms. Examining MCI …

Delineating the Heterogeneity of Alzheimer's Disease and Mild Cognitive Impairment Using Normative Models of the Dynamic Brain Functional Networks

Y Huo, R **g, P Li, P Chen, J Si, G Liu, Y Liu - Biological Psychiatry, 2024 - Elsevier
Abstract Background Alzheimer's Disease (AD), identified as the most common type of
dementia, presents considerable heterogeneity in clinical manifestations. Early intervention …

Comprehensive evaluation of AT (N) imaging biomarkers for predicting cognition

T Earnest, B Yang, D Kothapalli, A Sotiras… - medRxiv, 2024 - medrxiv.org
Background and Objectives: Imaging biomarkers enable in vivo quantification of amyloid,
tau, and neurogenerative pathologies that develop in Alzheimer's Disease (AD). Interest in …

The Effect of Al-Qur'an Recitation as Systematic Audio Therapy on Patients with Neurodegenerative Progressive Supranuclear Palsy (PSP): A Review

N Suryo, MH Syafi'i - Journal of Islamic Communication and …, 2024 - jicc.umy.ac.id
Al-Quran, as the holy book in the Islamic religion, is not only a spiritual guide but also has a
significant psychological impact on the individuals who read it. The Koran offers ethical and …

Characterizing the heterogeneity of neurodegenerative diseases through EEG normative modeling

M HASSAN, J Tabbal, A Ebadi, A Mheich, A Kabbara… - bioRxiv, 2024 - biorxiv.org
Neurodegenerative diseases such as Parkinson's (PD) and Alzheimer's (AD) exhibit
considerable heterogeneity of functional brain features within patient populations …

Artificial Intelligence in Drug Discovery and Repurposing for Neurodegenerative Disorders

ML Raza, MK Abbas - Integrating Neuroimaging, Computational …, 2025 - taylorfrancis.com
Neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, pose
escalating challenges to global healthcare systems due to an aging population. This chapter …

Integrating neurotransmitter receptor architecture in whole-brain computational models of neurodegenerative disease progression

A Khan - 2024 - escholarship.mcgill.ca
Alzheimer's disease (AD) and Parkinson's disease (PD) are among the prevailing causes of
dementia and movement disorder, respectively. These neurodegenerative diseases are …