Conspectus One of the fundamental goals of chemists is to develop highly efficient methods
for producing optically active compounds, given their wide range of applications in …

Enzymes are the core for biological transformations in nature. Their structures and functions
have drawn enormous attention from biologists as well as chemists since last century. The …

NMR chemical shifts provide detailed information on the chemical properties of molecules,
thereby complementing structural data from techniques like X-ray crystallography and …

γ-aminobutyric acid (GABA) is a non-protein amino acid which naturally and widely occurs in
animals, plants, and microorganisms. As the chief inhibitory neurotransmitter in the central …

Chiral amines are essential building blocks to manufacture a plethora of valuable
compounds, including active pharmaceutical ingredients (API). It is estimated that about half …

Carbanionic intermediates play a central role in the catalytic transformations of amino acids
performed by pyridoxal-5′-phosphate (PLP)-dependent enzymes. Here, we make use of …

Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of
biological amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) …

With 500 000 cases of multidrug‐resistant tuberculosis there is an urgent need for attractive
targets to enable the discovery of novel antimycobacterials. The biosynthesis of essential …

Unprecedented bacterial targets are urgently needed to overcome the resistance crisis.
Herein we systematically mine pyridoxal phosphate‐dependent enzymes (PLP‐DEs) in …

Vitamin B6 serves as universal co‐enzymes in biological systems. However, its catalytic
power has not been applied into the area of asymmetric catalysis. Based on the core …