Regenerative medicine and tissue engineering have seen unprecedented growth in the past
decade, driving the field of artificial tissue models towards a revolution in future medicine …

Stem cells hold great promise for widespread biomedical applications, for which stem cell
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …

Basic and Applied Bone Biology, Second Edition, provides an overview of skeletal biology,
from the molecular level, to the organ level, including cellular control, interaction and …

The importance of the vascular supply for bone is well-known to orthopaedists but is still
rather overlooked within the wider field of skeletal research. Blood supplies oxygen …

Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the
potential to contribute to both local and systemic metabolic processes. In this review we …

The current knowledge of bone marrow mechanics is limited to its viscous properties,
neglecting the elastic contribution of the extracellular matrix. To get a more complete view of …

Dental plaque accumulation may result in peri-implantitis, an inflammatory process causing
loss of supporting bone that may lead to dental implant failure. The antimicrobial activities of …

The phenotypic expression and function of stem cells are regulated by their integrated
response to variable microenvironmental cues, including growth factors and cytokines …

Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the
most promising alternative to autologous bone grafting. However, one of the limiting factors …

Extracellular matrix stiffness influences biological functions of some tumors. However, it
remains unclear how cancer subtypes with different oncogenic mutations respond to matrix …