Long non-coding RNAs: definitions, functions, challenges and recommendations

JS Mattick, PP Amaral, P Carninci… - … reviews Molecular cell …, 2023 - nature.com
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Long noncoding RNAs in cancer pathways

AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

Gene regulation in the immune system by long noncoding RNAs

YG Chen, AT Satpathy, HY Chang - Nature immunology, 2017 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …

Unique features of long non-coding RNA biogenesis and function

JJ Quinn, HY Chang - Nature reviews genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy

G Li, I Kryczek, J Nam, X Li, S Li, J Li, S Wei… - Nature cell …, 2021 - nature.com
Major histocompatibility complex-I (MHC-I) presents tumour antigens to CD8+ T cells and
triggers anti-tumour immunity. Humans may have 30,000–60,000 long noncoding RNAs …

Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling

Y Wang, L He, Y Du, P Zhu, G Huang, J Luo, X Yan… - Cell stem cell, 2015 - cell.com
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …

Epigenetic mechanisms in neurogenesis

B Yao, KM Christian, C He, P **, G Ming… - Nature reviews …, 2016 - nature.com
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …

Long noncoding RNAs in cancer: mechanisms of action and technological advancements

N Bartonicek, JLV Maag, ME Dinger - Molecular cancer, 2016 - Springer
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …

Long non-coding RNAs and their functions in plants

JA Chekanova - Current opinion in plant biology, 2015 - Elsevier
Highlights•Plant lncRNAs participate in regulation of transcription, splicing, and nuclear
structure.•In flowering, multiple lncRNAs act in silencing of FLC via diverse …