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Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Long noncoding RNAs in cancer pathways
AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …
mutations within the noncoding genome, with profound effects on the expression of long …
Gene regulation in the immune system by long noncoding RNAs
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
Unique features of long non-coding RNA biogenesis and function
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …
biological processes across every branch of life. Although initially discovered as mRNA-like …
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy
Major histocompatibility complex-I (MHC-I) presents tumour antigens to CD8+ T cells and
triggers anti-tumour immunity. Humans may have 30,000–60,000 long noncoding RNAs …
triggers anti-tumour immunity. Humans may have 30,000–60,000 long noncoding RNAs …
Long noncoding RNAs as biomarkers in cancer
L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
Epigenetic mechanisms in neurogenesis
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …
being defined as a category of genetic elements, leaving its mark on the field of cancer …
Long non-coding RNAs and their functions in plants
JA Chekanova - Current opinion in plant biology, 2015 - Elsevier
Highlights•Plant lncRNAs participate in regulation of transcription, splicing, and nuclear
structure.•In flowering, multiple lncRNAs act in silencing of FLC via diverse …
structure.•In flowering, multiple lncRNAs act in silencing of FLC via diverse …