Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

The role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and
non-alcoholic steatohepatitis (NASH) is not well understood. To examine this, we performed …

Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health
expenditures worldwide. Obesity is a significant risk factor for CKD development, partially …

Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

The present study aims to provide a narrative review of the molecular mechanisms of
Western diet-induced obesity and obesity-related carcinogenesis. A literature search of the …

Inflammation is an essential physiological defence mechanism, but prolonged or excessive
inflammation can cause disease. Indeed, unresolved systemic and adipose tissue …

Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis,
and the development of a secretome that can be pro-inflammatory. In aging and obesity …