Pharmacogenomics: driving personalized medicine
Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
Pharmacological modulation of cholesterol 7α-hydroxylase (CYP7A1) as a therapeutic strategy for hypercholesterolemia
MYC Lim, HK Ho - Biochemical Pharmacology, 2024 - Elsevier
Despite the availability of many therapeutic options, the prevalence of hypercholesterolemia
remains high. There exists a significant unmet medical need for novel drugs and/or …
remains high. There exists a significant unmet medical need for novel drugs and/or …
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting
0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus …
0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus …
Changes in circulating bile acid subtypes in response to weight-loss diets are associated with improvements in glycemic status and insulin resistance: The POUNDS …
Objective Various primary and secondary bile acids (BAs) may play pivotal roles in
glucose/insulin metabolism. We investigated whether changes in specific BA subtypes were …
glucose/insulin metabolism. We investigated whether changes in specific BA subtypes were …
[HTML][HTML] Changes in bile acid subtypes and improvements in lipid metabolism and atherosclerotic cardiovascular disease risk: the Preventing Overweight Using Novel …
Background Distinct circulating bile acid (BA) subtypes may play roles in regulating lipid
homeostasis and atherosclerosis. Objectives We investigated whether changes in …
homeostasis and atherosclerosis. Objectives We investigated whether changes in …
Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review
Inonotus obliquus, also known as Chaga, is a medicinal mushroom that has been used for
therapeutic purposes since the sixteenth century. Collections of folk medicine record the …
therapeutic purposes since the sixteenth century. Collections of folk medicine record the …
[HTML][HTML] A non-coding disease modifier of pancreatic agenesis identified by genetic correction in a patient-derived iPSC line
GATA6 is a critical regulator of pancreatic development, with heterozygous mutations in this
transcription factor being the most common cause of pancreatic agenesis. To study the …
transcription factor being the most common cause of pancreatic agenesis. To study the …
Intestinal population in host with metabolic syndrome during administration of chitosan and its derivatives
C Yan, C Zhang, X Cao, B Feng, X Li - Molecules, 2020 - mdpi.com
Chitosan and its derivatives can alleviate metabolic syndrome by different regulation
mechanisms, phosphorylation of AMPK (AMP-activated kinase) and Akt (also known as …
mechanisms, phosphorylation of AMPK (AMP-activated kinase) and Akt (also known as …
A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins
Background and Aims: Various publications suggested that there is an association between
CYP7A1 single nucleotide polymorphisms (SNP) and a reduced response to statin therapy …
CYP7A1 single nucleotide polymorphisms (SNP) and a reduced response to statin therapy …
Genes potentially associated with familial hypercholesterolemia
S Mikhailova, D Ivanoshchuk, O Timoshchenko… - Biomolecules, 2019 - mdpi.com
This review addresses the contribution of some genes to the phenotype of familial
hypercholesterolemia. At present, it is known that the pathogenesis of this disease involves …
hypercholesterolemia. At present, it is known that the pathogenesis of this disease involves …