Bcl-2 is an oncogenic protein that acts by inhibiting programmed cell death. The
mechanisms used by this and related anti-apoptotic proteins to protect cells from cytotoxic …

The p53 tumor suppressor limits cellular proliferation by inducing cell cycle arrest and
apoptosis in response to cellular stresses such as DNA damage, hypoxia, and oncogene …

The bax gene promoter region contains four motifs with homology to consensus p53-binding
sites. In cotransfection assays using p53-deficient tumor cell lines, wild-type but not mutant …

A green fluorescent protein (GFP)–Raf-1 fusion protein was used to show that Bcl-2 can
target this kinase to mitochondria. Active Raf-1 fused with targeting sequences from an outer …

The BCL‐2 gene was first discovered because of its involvement in the t (14; 18)
chromosomal translocations commonly found in lymphomas, which result in deregulation of …

The field of apoptosis is unusual in several respects. Firstly, its general importance has been
widely recognised only in the past few years and its surprising significance is still being …

The Bcl-2 family of proteins plays a pivotal role in regulating cell life and death. Many of
these proteins reside in the outer mitochondrial membrane, oriented towards the cytosol …

Bcl-2 is the prototype of a class of oncogenes which regulates apoptosis. Bcl-2-related gene
products with either death-promoting and death-inhibitory activity are critically involved in …

Bcl-2 is the prototypical member of a large family of apoptosis-regulating proteins, consisting
of blockers and promoters of cell death. The three-dimensional structure of a Bcl-2 …

Nuclear protein transport is integral to eukaryotic cell processes such as differentiation,
transformation, and the control of gene expression. Although the targeting role of nuclear …