Tissue homeostasis and inflammation

ML Meizlish, RA Franklin, X Zhou… - Annual review of …, 2021 - annualreviews.org
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …

Innate lymphoid cells and cancer

N Jacquelot, C Seillet, E Vivier, GT Belz - Nature Immunology, 2022 - nature.com
The innate lymphoid cell (ILC) family is composed of natural killer (NK) cells, ILC1, ILC2 and
ILC3, which participate in immune responses to virus, bacteria, parasites and transformed …

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

M Lv, M Chen, R Zhang, W Zhang, C Wang, Y Zhang… - Cell research, 2020 - nature.com
CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …

CD4 T helper cell subsets and related human immunological disorders

X Zhu, J Zhu - International journal of molecular sciences, 2020 - mdpi.com
The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

Microbial genes and pathways in inflammatory bowel disease

M Schirmer, A Garner, H Vlamakis… - Nature Reviews …, 2019 - nature.com
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease
(IBD). Studies of treatment-naive patients have identified microbial taxa associated with …

IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation

W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

MG Constantinides, VM Link, S Tamoutounour… - Science, 2019 - science.org
INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …

Commensal-driven immune zonation of the liver promotes host defence

A Gola, MG Dorrington, E Speranza, C Sala, RM Shih… - Nature, 2021 - nature.com
The liver connects the intestinal portal vasculature with the general circulation, using a
diverse array of immune cells to protect from pathogens that translocate from the gut. In liver …

The role of IL-22 in intestinal health and disease

ME Keir, T Yi, TT Lu, N Ghilardi - Journal of Experimental Medicine, 2020 - rupress.org
The role of IL-22 in intestinal health and disease | Journal of Experimental Medicine |
Rockefeller University Press Skip to Main Content Advertisement Umbrella Alt Text …

A weaning reaction to microbiota is required for resistance to immunopathologies in the adult

Z Al Nabhani, S Dulauroy, R Marques, C Cousu… - Immunity, 2019 - cell.com
Microbes colonize all body surfaces at birth and participate in the development of the
immune system. In newborn mammals, the intestinal microbiota is first shaped by the dietary …