Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Control of integrin affinity for ligands (integrin activation) is essential for normal cell
adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually …

How ligand binding alters integrin conformation in outside-in signaling, and how inside-out
signals alter integrin affinity for ligand, have been mysterious. We address this with electron …

Integrins are αβ heterodimeric receptors that mediate divalent cation-dependent cell-cell
and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved …

Integrins are transmembrane cell–adhesion molecules that carry signals from the outside to
the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in …