Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
Mechanisms of viral mutation
R Sanjuán, P Domingo-Calap - Cellular and molecular life sciences, 2016 - Springer
The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …
dependent on their ability to generate de novo diversity in a short period of time. Rates of …
APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016
Historically, mpox has been characterized as an endemic zoonotic disease that transmits
through contact with the reservoir rodent host in West and Central Africa. However, in May …
through contact with the reservoir rodent host in West and Central Africa. However, in May …
Rampant C→ U hypermutation in the genomes of SARS-CoV-2 and other coronaviruses: causes and consequences for their short-and long-term evolutionary …
P Simmonds - Msphere, 2020 - Am Soc Microbiol
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
motivated an intensive analysis of its molecular epidemiology following its worldwide …
motivated an intensive analysis of its molecular epidemiology following its worldwide …
Six reference-quality genomes reveal evolution of bat adaptations
Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …
and unique immunity. High-quality genomes are crucial for understanding the molecular …
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
J Lucifora, Y **a, F Reisinger, K Zhang, D Stadler… - Science, 2014 - science.org
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …
[HTML][HTML] Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution
Members of the APOBEC family of cytidine deaminases show antiviral activities in
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
Prisoners of war—host adaptation and its constraints on virus evolution
Recent discoveries of contemporary genotypes of hepatitis B virus and parvovirus B19 in
ancient human remains demonstrate that little genetic change has occurred in these viruses …
ancient human remains demonstrate that little genetic change has occurred in these viruses …
[КНИГА][B] RNA, the epicenter of genetic information
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …