The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture …

The fidelity of intracellular signaling hinges on the organization of dynamic activity
architectures. Spatial compartmentation was first proposed over 30 years ago to explain how …

Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

Activity-dependent plasticity of synaptic structure and function plays an essential role in
neuronal development and in cognitive functions including learning and memory. The …

Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …

Semaphorins are key players in the control of neural circuit development. Recent studies
have uncovered several exciting and novel aspects of neuronal semaphorin signalling in …

In the mammalian brain, the specification of a single axon and multiple dendrites occurs
early in the differentiation of most neuron types. Numerous intracellular signaling events for …

A critical step in neuronal development is the formation of axon/dendrite polarity, a process
involving symmetry breaking in the newborn neuron. Local self-amplifying processes could …

Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second
messenger cyclic adenosine 3′, 5′ monophosphate (cAMP). sAC is distinct from the more …