Cancer‐associated‐platelet‐inspired nanomedicines for cancer therapy
Platelets, with hemostasis and thrombosis activities, are one of the key components in the
blood circulation. As a guard, they rapidly respond to any abnormal blood vessel injury …
blood circulation. As a guard, they rapidly respond to any abnormal blood vessel injury …
Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets
Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is
prevented by regulating mechanisms which affect the expression and function of either …
prevented by regulating mechanisms which affect the expression and function of either …
Intravascular leukocyte migration through platelet thrombi: directing leukocytes to sites of vascular injury
Leukocytes recruitment to thrombi supports an intimate cellular interaction leading to the
enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular …
enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular …
Intraplatelet reactive oxygen species (ROS) correlate with the shedding of adhesive receptors, microvesiculation and platelet adhesion to collagen during storage …
Platelets storage lesion is mainly orchestrated by platelet activating signals during storage.
Reactive oxygen species (ROS) are being considered as important signaling molecules …
Reactive oxygen species (ROS) are being considered as important signaling molecules …
Molecular Biomarkers for In Vitro Thrombogenicity Assessment of Medical Device Materials
M Patel, A Parrish, C Serna III… - … Research Part B …, 2024 - Wiley Online Library
To develop standardized in vitro thrombogenicity test methods for evaluating medical device
materials, three platelet activation biomarkers, beta‐thromboglobulin (β‐TG), platelet factor 4 …
materials, three platelet activation biomarkers, beta‐thromboglobulin (β‐TG), platelet factor 4 …
GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion
Platelet storage is associated with deleterious changes leading to the loss of platelet
reactivity and response. During storage, platelets experience increased expression and …
reactivity and response. During storage, platelets experience increased expression and …
Reverse correlations of collagen-dependent platelet aggregation and adhesion with GPVI shedding during storage
Platelet receptor GPVI plays an important role in platelet firm adhesion to site of vascular
injury. Receptor ligation with collagen, in company with other agonist/receptor interactions …
injury. Receptor ligation with collagen, in company with other agonist/receptor interactions …
Collagen-dependent platelet dysfunction and its relevance to either mitochondrial ROS or cytosolic superoxide generation: a question about the quality and functional …
E Hosseini, S Hojjati, S Afzalniaye gashti… - Thrombosis …, 2020 - Springer
Background Upon vascular damage, the exposed subendothelial matrix recruits circulating
platelets to site of injury while inducing their firm adhesion mainly via GPVI-collagen …
platelets to site of injury while inducing their firm adhesion mainly via GPVI-collagen …
Platelet spreading on fibrinogen matrix, a reliable and sensitive marker of platelet functional activity during storage
Upon platelet activation, inside-out signals synergistically induced by a variety of agonists
and adhesion molecules can enhance the affinity of platelet main integrin, α IIb β 3 to its …
and adhesion molecules can enhance the affinity of platelet main integrin, α IIb β 3 to its …
Molecular aspects of pathophysiology of platelet receptors
MK Poddar, S Banerjee - Platelets, 2020 - books.google.com
Receptor is a dynamic instrumental surface protein that helps to interact with specific
molecules to respond accordingly. Platelet is the smallest in size among the blood …
molecules to respond accordingly. Platelet is the smallest in size among the blood …