Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Engineered living materials for advanced diseases therapy

X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

Cloaking mesoporous polydopamine with bacterial membrane vesicles to amplify local and systemic antitumor immunity

W Chen, Y Song, S Bai, C He, Z Guo, Y Zhu, Z Zhang… - ACS …, 2023 - ACS Publications
As adjuvants or antigens, bacterial membranes have been widely used in recent
antibacterial and antitumor research, but they are often injected multiple times to achieve …

Microbe-material hybrids for therapeutic applications

M Chen, L **a, C Wu, Z Wang, L Ding, Y **e… - Chemical Society …, 2024 - pubs.rsc.org
As natural living substances, microorganisms have emerged as useful resources in
medicine for creating microbe-material hybrids ranging from nano to macro dimensions. The …

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

L Zhao, J Chen, B Bai, G Song, J Zhang, H Yu… - Frontiers in …, 2024 - frontiersin.org
Topical drug delivery is widely used in various diseases because of the advantages of not
passing through the gastrointestinal tract, avoiding gastrointestinal irritation and hepatic first …

Novel strategies for modulating the gut microbiome for cancer therapy

YS Cho, K Han, J Xu, JJ Moon - Advanced Drug Delivery Reviews, 2024 - Elsevier
Recent advancements in genomics, transcriptomics, and metabolomics have significantly
advanced our understanding of the human gut microbiome and its impact on the efficacy …

Novel approaches in IBD therapy: Targeting the gut microbiota-bile acid axis

Y Pan, H Zhang, M Li, T He, S Guo, L Zhu, J Tan… - Gut …, 2024 - Taylor & Francis
Inflammatory bowel disease (IBD) is a chronic and recurrent condition affecting the
gastrointestinal tract. Disturbed gut microbiota and abnormal bile acid (BA) metabolism are …

The potential use of bacteria and bacterial derivatives as drug delivery systems for viral infection

A Faghihkhorasani, HH Ahmed, NM Mashool, M Alwan… - Virology Journal, 2023 - Springer
Viral infections in humans are responsible for fatalities worldwide and contribute to the
incidence of various human ailments. Controllable targeted medicine delivery against many …

[HTML][HTML] Emerging frontiers in drug delivery with special focus on novel techniques for targeted therapies

L Yu, S Liu, S Jia, F Xu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The management and treatment of disease are achieved via the use of pharmacologically
active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; …

Phage lysins for intestinal microbiome modulation: current challenges and enabling techniques

I Pottie, R Vázquez Fernández, T Van de Wiele… - Gut …, 2024 - Taylor & Francis
The importance of the microbiota in the intestinal tract for human health has been
increasingly recognized. In this perspective, microbiome modulation, a targeted alteration of …