The p53 pathway has been shown to mediate cellular stress responses; p53 can initiate
DNA repair, cell-cycle arrest, senescence and, importantly, apoptosis. These responses …

AMPK is an evolutionarily conserved fuel-sensing enzyme that is activated in shortage of
energy and suppressed in its surfeit. AMPK activation stimulates fatty acid oxidation …

Proliferating cells exhibit a metabolic phenotype known as" aerobic glycolysis," which is
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …

Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these
cells has recently emerged as a promising therapeutic approach. Here, we take advantage …

Cell lines are invaluable biomedical research tools, and recent literature has emphasized
the importance of genotype authentication and characterization. In the present study, 24 out …

The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years.
With a 5-year survival rate of∼ 15%, the identification of new therapeutic targets for EAC is …

High-throughput and high-content databases are increasingly important resources in
molecular medicine, systems biology, and pharmacology. However, the information usually …

Brain metastatic breast cancer (BMBC) is uniformly fatal and increasing in frequency.
Despite its devastating outcome, mechanisms causing BMBC remain largely unknown. The …

Background To leverage the potential of multi-omics studies, exploratory data analysis
methods that provide systematic integration and comparison of multiple layers of omics …

Systematic efforts are underway to decipher the genetic changes associated with tumor
initiation and progression,. However, widespread clinical application of this information is …