The human Y chromosome harbors genes that are responsible for testis development and
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …

▪ Abstract Cys2His2 zinc fingers are one of the most common DNA-binding motifs found in
eukaryotic transcription factors. These proteins typically contain several fingers that make …

Background Exosomes are small membrane vesicles with a size of 40-100 nm that are
released by different cell types from a late endosomal cellular compartment. They can be …

A search of a 35-kilobase region of the human Y chromosome necessary for male sex
determination has resulted in the identification of a new gene. This gene is conserved and Y …

An understanding of the basic defect in the inherited disorder cystic fibrosis requires cloning
of the cystic fibrosis gene and definition of its protein product. In the absence of direct …

A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares
notable sequence similarity with a segment of the cellular Myc transforming protein. Display …

A gene map** to the sex-determining region of the mouse Y chromosome is deleted in a
line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal …

The application of recombinant DNA technology to prenatal diagnosis of many recessively
inherited X-linked diseases is complicated by a high frequency of heterogenous, new …

Human sex chromosomes evolved from autosomes. Nineteen ancestral autosomal genes
persist as differentiated homologs on the X and Y chromosomes. The ages of individual XY …

THE development of a eutherian mammal as a male is a consequence of testis formation in
the embryo, which is thought to be initiated by a gene on the Y chromosome. In the absence …