A fluid-to-solid jamming transition underlies vertebrate body axis elongation

A Mongera, P Rowghanian, HJ Gustafson, E Shelton… - Nature, 2018 - nature.com
Just as in clay moulding or glass blowing, physically sculpting biological structures requires
the constituent material to locally flow like a fluid while maintaining overall mechanical …

Molecular mechanism of GPCR spatial organization at the plasma membrane

G Kockelkoren, L Lauritsen, CG Shuttle… - Nature Chemical …, 2024 - nature.com
G-protein-coupled receptors (GPCRs) mediate many critical physiological processes. Their
spatial organization in plasma membrane (PM) domains is believed to encode signaling …

Fluorous soluble cyanine dyes for visualizing perfluorocarbons in living systems

I Lim, A Vian, HL van de Wouw, RA Day… - Journal of the …, 2020 - ACS Publications
The bioorthogonal nature of perfluorocarbons provides a unique platform for introducing
dynamic nano-and microdroplets into cells and organisms. To monitor the localization and …

Spatiotemporal variation of endogenous cell-generated stresses within 3D multicellular spheroids

AA Lucio, A Mongera, E Shelton, R Chen, AM Doyle… - Scientific reports, 2017 - nature.com
Multicellular spheroids serve as an excellent platform to study tissue behavior and tumor
growth in a controlled, three-dimensional (3D) environment. While molecular and cellular …

STRESS, an automated geometrical characterization of deformable particles for in vivo measurements of cell and tissue mechanical stresses

B Gross, E Shelton, C Gomez, O Campàs - bioRxiv, 2021 - biorxiv.org
From cellular mechanotransduction to the formation of embryonic tissues and organs,
mechanics has been shown to play an important role in the control of cell behavior and …

GeoV: An Open‐Source Software Package for Quantitative Image Analysis of 3D Vesicle Morphologies

Y Dreher, J Niessner, A Fink… - Advanced Intelligent …, 2023 - Wiley Online Library
Bottom‐up synthetic biology has reconstituted processes like adhesion, cortex formation, or
division of giant lipid vesicles (GUVs), which all rely on changes in the vesicle morphology …

[LIVRE][B] Quantifying the forces that drive zebrafish axis elongation and somitogenesis

ER Shelton - 2021 - search.proquest.com
The study of morphogenesis in animals is concerned with the question of how the structures
composing the body acquire their form during embryonic development. As cells are able to …

[LIVRE][B] Optimization of Microdroplet-based Techniques to Measure Mechanical Stresses in 3D Multicellular Systems

A Lucio - 2018 - search.proquest.com
In addition to the well-established influence that soluble factors have on cellular behavior,
physical forces are also now known to play a large role. Many cellular processes such as …