Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact
E De Clercq - Advances in virus research, 1993 - Elsevier
Publisher Summary This chapter proposes a theory based on experience with different
classes of antiviral compounds, that a detailed analysis of the antiviral activity spectrum of a …
classes of antiviral compounds, that a detailed analysis of the antiviral activity spectrum of a …
Antiviral chemotherapy for the treatment of hepatitis B virus infections
J Torresi, S Locarnini - Gastroenterology, 2000 - Elsevier
Approximately 5% of the world's human population have an increased risk for develo**
liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B …
liver cancer and cirrhosis as a direct consequence of chronic infection with the hepatitis B …
Inhibition of the replication of hepatitis B virus in vitro by 2', 3'-dideoxy-3'-thiacytidine and related analogues.
SL Doong, CH Tsai, RF Schinazi… - Proceedings of the …, 1991 - National Acad Sciences
Several 2', 3'-dideoxy-3'-thiapyrimidine nucleosides were studied for their ability to inhibit
hepatitis B virus (HBV) DNA replication in a HBV-transfected cell line (2.2. 15). 2', 3'-Dideoxy …
hepatitis B virus (HBV) DNA replication in a HBV-transfected cell line (2.2. 15). 2', 3'-Dideoxy …
Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus
SF Innaimo, M Seifer, GS Bisacchi… - Antimicrobial agents …, 1997 - Am Soc Microbiol
BMS-200475 is a novel carbocyclic 2'-deoxyguanosine analog found to possess potent and
selective anti-hepatitis B virus (anti-HBV) activity. BMS-200475 is distinguished from …
selective anti-hepatitis B virus (anti-HBV) activity. BMS-200475 is distinguished from …
Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.
The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the
oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains …
oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains …
[BUKU][B] Biocatalysis in the pharmaceutical and biotechnology industries
RN Patel - 2006 - taylorfrancis.com
Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity,
substrate specificity, and stability, they require mild conditions to react while prompting …
substrate specificity, and stability, they require mild conditions to react while prompting …
Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication
BE Korba, JL Gerin - Antiviral Research, 1992 - Elsevier
A cell culture system for the evaluation of compounds which inhibit HBV replication (Korba
and Milman, Antiviral Res. 15: 217, 1991) has been developed into a standardized assay …
and Milman, Antiviral Res. 15: 217, 1991) has been developed into a standardized assay …
Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity
J Köck, HJ Schlicht - Journal of virology, 1993 - Am Soc Microbiol
Hepadnaviruses contain a relaxed circular DNA genome (RC-DNA) with discontinuities in
both strands. Upon infectious entry into a host cell, this genome is converted into a …
both strands. Upon infectious entry into a host cell, this genome is converted into a …
[HTML][HTML] Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2', 3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
CN Chang, SL Doong, JH Zhou, JW Beach… - Journal of Biological …, 1992 - Elsevier
2', 3'-Dideoxy-3'-thiacytidine (+/-)-SddC) was found to have potent activity against human
hepatitis B virus as well as human immunodeficiency viruses in culture. The (-) form ((-) …
hepatitis B virus as well as human immunodeficiency viruses in culture. The (-) form ((-) …
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1, 3-oxathiolan-5-yl] cytosine
PA Furman, M Davis, DC Liotta, M Paff… - Antimicrobial Agents …, 1992 - Am Soc Microbiol
The anti-hepatitis B (anti-HBV) activities of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-
(hydroxymethyl)-1, 3-oxathiolan-5-yl] cytosine (2'-deoxy-3'-thia-5-fluorocytosine [FTC]) were …
(hydroxymethyl)-1, 3-oxathiolan-5-yl] cytosine (2'-deoxy-3'-thia-5-fluorocytosine [FTC]) were …