Synonymous but not silent: the codon usage code for gene expression and protein folding
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …
Although synonymous mutations were previously thought to be silent, a large body of …
A code within the genetic code: codon usage regulates co-translational protein folding
Y Liu - Cell Communication and Signaling, 2020 - Springer
The genetic code is degenerate, and most amino acids are encoded by two to six
synonymous codons. Codon usage bias, the preference for certain synonymous codons, is a …
synonymous codons. Codon usage bias, the preference for certain synonymous codons, is a …
Inosine in biology and disease
The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and
modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post …
modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post …
Cotranslational mechanisms of protein biogenesis and complex assembly in eukaryotes
The formation of protein complexes is crucial to most biological functions. The cellular
mechanisms governing protein complex biogenesis are not yet well understood, but some …
mechanisms governing protein complex biogenesis are not yet well understood, but some …
Codon usage and protein length-dependent feedback from translation elongation regulates translation initiation and elongation speed
Essential cellular functions require efficient production of many large proteins but synthesis
of large proteins encounters many obstacles in cells. Translational control is mostly known to …
of large proteins encounters many obstacles in cells. Translational control is mostly known to …
Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3
LG Dolce, AA Zimmer, L Tengo, F Weis… - Nature …, 2022 - nature.com
The essential deamination of adenosine A34 to inosine at the wobble base is the individual
tRNA modification with the greatest effects on mRNA decoding, empowering a single tRNA …
tRNA modification with the greatest effects on mRNA decoding, empowering a single tRNA …
The occurrence, characteristics, and adaptation of A-to-I RNA editing in bacteria: A review
A-to-I RNA editing is a very important post-transcriptional modification or co-transcriptional
modification that creates isoforms and increases the diversity of proteins. In this process …
modification that creates isoforms and increases the diversity of proteins. In this process …
[HTML][HTML] Emerging functions of tRNA modifications in mRNA translation and diseases
L Wang, S Lin - Journal of Genetics and Genomics, 2023 - Elsevier
Abstract tRNAs are essential modulators that recognize mRNA codons and bridge amino
acids for mRNA translation. The tRNAs are heavily modified, which are essential for forming …
acids for mRNA translation. The tRNAs are heavily modified, which are essential for forming …
Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules
RNA modifications have attracted increasing interest in recent years because they have
been frequently implicated in various human diseases, including cancer, highlighting the …
been frequently implicated in various human diseases, including cancer, highlighting the …
RNA editing enzymes: structure, biological functions and applications
D Zhang, L Zhu, Y Gao, Y Wang, P Li - Cell & Bioscience, 2024 - Springer
With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …
different RNA modifications have been identified. However, only a few of these modifications …