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Nephrotoxicity from vancomycin combined with piperacillin-tazobactam: a comprehensive review
M Blair, JM Côté, A Cotter, B Lynch… - American journal of …, 2021 - karger.com
Background: Recent studies have identified the combination of vancomycin with piperacillin-
tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort …
tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort …
Cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection: the ACORN randomized clinical trial
Importance Cefepime and piperacillin-tazobactam are commonly administered to
hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has …
hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has …
Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study
Purpose Although dozens of studies have associated vancomycin+ piperacillin–tazobactam
with increased acute kidney injury (AKI) risk, it is unclear whether the association represents …
with increased acute kidney injury (AKI) risk, it is unclear whether the association represents …
Efficacy and mechanism of actions of natural antimicrobial drugs
Microbial infections have significantly increased over the last decades, and the mortality
rates remain unacceptably high. The emergence of new resistance patterns and the spread …
rates remain unacceptably high. The emergence of new resistance patterns and the spread …
Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury
Background Piperacillin/tazobactam, a commonly used antibiotic, is associated with acute
kidney injury (AKI). The relationship between piperacillin concentrations and AKI remains …
kidney injury (AKI). The relationship between piperacillin concentrations and AKI remains …
Balancing the scales: achieving the optimal beta-lactam to beta-lactamase inhibitor ratio with continuous infusion piperacillin/tazobactam against extended spectrum …
Piperacillin/tazobactam (TZP) is administered intravenously in a fixed ratio (8: 1) with the
potential for inadequate tazobactam exposure to ensure piperacillin activity against …
potential for inadequate tazobactam exposure to ensure piperacillin activity against …
Piperacillin-tazobactam added to vancomycin increases risk for acute kidney injury: fact or fiction?
Vancomycin and piperacillin-tazobactam are 2 of the most commonly prescribed antibiotics
in hospitals. Recent data from multiple meta-analyses suggest that the combination …
in hospitals. Recent data from multiple meta-analyses suggest that the combination …
New antibiotics for the treatment of nosocomial central nervous system infections
R Nau, J Seele, H Eiffert - Antibiotics, 2024 - mdpi.com
Nosocomial central nervous system (CNS) infections with carbapenem-and colistin-resistant
Gram-negative and vancomycin-resistant Gram-positive bacteria are an increasing …
Gram-negative and vancomycin-resistant Gram-positive bacteria are an increasing …
Incorporating ontogeny in physiologically based pharmacokinetic modeling to improve pediatric drug development: what we know about developmental changes in …
KWK Cheung, BD van Groen… - The Journal of …, 2019 - Wiley Online Library
Developmental changes in the biological processes involved in the disposition of drugs,
such as membrane transporter expression and activity, may alter the drug exposure and …
such as membrane transporter expression and activity, may alter the drug exposure and …
Piperacillin/tazobactam and risk of acute kidney injury in adults hospitalized with infection without vancomycin: a multi-centre real-world data analysis
Background There is uncertainty about whether piperacillin/tazobactam (PT) increases the
risk of acute kidney injury (AKI) in patients without concomitant use of vancomycin. This …
risk of acute kidney injury (AKI) in patients without concomitant use of vancomycin. This …