Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

L Cheng, J Wang, H Dai, Y Duan, Y An, L Shi, Y Lv… - Adipocyte, 2021 - Taylor & Francis
Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

Recent update on the molecular mechanisms of gonadal steroids action in adipose tissue

A Wawrzkiewicz-Jałowiecka, A Lalik… - International Journal of …, 2021 - mdpi.com
The gonadal steroids, including androgens, estrogens and progestogens, are involved in
the control of body fat distribution in humans. Nevertheless, not only the size and localization …

Hypoglycemic effect of the polysaccharides from Astragalus membranaceus on type 2 diabetic mice based on the “gut microbiota–mucosal barrier”

X Chen, C Chen, X Fu - Food & Function, 2022 - pubs.rsc.org
Astragalus membranaceus polysaccharides (APP), the main active constituent, possess
numerous bioactivities. In this research, a type 2 diabetes mellitus (T2DM) mouse model …

[HTML][HTML] Role of bile acid receptor FXR in development and function of brown adipose tissue

J Yang, HD de Vries, A Mayeuf-Louchart… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Bile acids act as signalling molecules that contribute to maintenance of energy homeostasis
in mice and humans. Activation of G-protein-coupled bile acid receptor TGR5 induces …

[HTML][HTML] Adipose Tissue Plasticity: A Comprehensive Definition and Multidimensional Insight

YY Mo, YX Han, SN Xu, HL Jiang, HX Wu, JM Cai, L Li… - Biomolecules, 2024 - mdpi.com
Adipose tissue is composed of adipocytes, stromal vascular fraction, nerves, surrounding
immune cells, and the extracellular matrix. Under various physiological or pathological …

Co-treatment with miR-21-5p inhibitor and Aurora kinase inhibitor reversine suppresses breast cancer progression by targeting sprouty RTK signaling antagonist 2

Y Zhang, Y Wang, J Xue, W Liang, Z Zhang… - …, 2022 - Taylor & Francis
Numerous studies have reported the regulatory effects of miR-21-5p and reversine in human
breast cancer (HBC). However, the mechanism of reversine and miR-21-5p has not been …

MicroRNAs as mediators of adipose thermogenesis and potential therapeutic targets for obesity

L Ma, A Gilani, Q Yi, L Tang - Biology, 2022 - mdpi.com
Simple Summary Thermogenesis in beige and brown adipose tissue has a significant role in
combating metabolic disorders, such as type 2 diabetes and diet-induced obesity. A large …

The Effects of DDI1 on Inducing Differentiation in Ovine Preadipocytes via Oar-miR-432

M **, Z Yuan, T Li, H Wang, C Wei - International Journal of Molecular …, 2023 - mdpi.com
Reducing fat deposition in sheep (Ovis aries) tails is one of the most important ways to
combat rising costs and control consumer preference. Our previous studies have shown that …

Develo** miR‐133a Zipper Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation

SA Yi, T Pongkulapa, S Nevins… - Advanced …, 2024 - Wiley Online Library
Existing delivery methods for RNAi therapeutics encounter challenges, including stability,
specificity, and off‐target effects, which restrict their clinical effectiveness. In this study, we …

Zinc improves semen parameters in high-fat diet-induced male rats by regulating the expression of LncRNA in testis tissue

J Ma, J Bi, B Sun, H Li, Y Li, S Wang - Biological trace element research, 2023 - Springer
This study aimed to identify differentially expressed LncRNAs in testis tissue of male rats
induced by high-fat diet and their changes after zinc supplementation, by constructing a high …