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A guide to the composition and functions of the extracellular matrix
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …
provides structural support for the cells and tissues. Accumulated knowledge clearly …
Update on adipose tissue and cancer
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
[HTML][HTML] PPARgamma in metabolism, immunity, and cancer: unified and diverse mechanisms of action
M Hernandez-Quiles, MF Broekema… - Frontiers in …, 2021 - frontiersin.org
The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …
is one of the most extensively studied ligand-inducible transcription factors. Since its …
[HTML][HTML] Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
Obesity, type 2 diabetes, and cancer risk
T Scully, A Ettela, D LeRoith, EJ Gallagher - Frontiers in oncology, 2021 - frontiersin.org
Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …
Extracellular matrix (ECM) and fibrosis in adipose tissue: overview and perspectives
Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …
[HTML][HTML] Adipocyte mesenchymal transition contributes to mammary tumor progression
Obesity is associated with increased cancer incidence and progression. However, the
relationship between adiposity and cancer remains poorly understood at the mechanistic …
relationship between adiposity and cancer remains poorly understood at the mechanistic …
Obesity: a perfect storm for carcinogenesis
BHL Harris, VM Macaulay, DA Harris… - Cancer and Metastasis …, 2022 - Springer
Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …
obesity is overtaking smoking as the most widespread modifiable risk factor for …
[HTML][HTML] Matrikines as mediators of tissue remodelling
Extracellular matrix (ECM) proteins confer biomechanical properties, maintain cell
phenotype and mediate tissue repair (via release of sequestered cytokines and proteases) …
phenotype and mediate tissue repair (via release of sequestered cytokines and proteases) …
The functional role of extracellular matrix proteins in cancer
Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …