The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Background & Aims: microRNAs (miRNAs) are short noncoding RNAs that regulate gene
expression negatively. Although a role for aberrant miRNA expression in cancer has been …

Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the
scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent …

MicroRNA-122 (miR-122), which accounts for 70% of the liver's total miRNAs, plays a pivotal
role in the liver. However, its intrinsic physiological roles remain largely undetermined. We …

Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the
molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the …

miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism
and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in …

MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of
gene expression. Recently, miRNAs have been implicated in several cancers. However …

• miR‐21 expression in cancer and other diseases• Mechanisms of miR‐21 elevation in
cancer: multi‐level regulatory control• Transcriptional control• Post‐trancriptional regulation• …

Purpose More than 60% of patients with hepatocellular carcinoma (HCC) do not receive
curative therapy as a result of late clinical presentation and diagnosis. We aimed to identify …