Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China

Z Zhang, K He, C Chi, Z Hu, J Tian - European Journal of Nuclear Medicine …, 2022 - Springer
Purpose China has the largest cancer population globally. Surgery is the main choice for
most solid cancer patients. Intraoperative fluorescence molecular imaging (FMI) has shown …

Precision surgery guided by intraoperative molecular imaging

F Azari, K Zhang, GT Kennedy, A Chang… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Intraoperative molecular imaging (IMI) has recently emerged as an important tool in the
armamentarium of surgical oncologists. IMI allows real-time assessment of oncologic …

A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection

GT Kennedy, DE Holt, FS Azari, E Bernstein… - Clinical Cancer …, 2022 - AACR
Purpose: Fluorescence-guided surgery using tumor-targeted contrast agents has been
developed to improve the completeness of oncologic resections. Quenched activity–based …

Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy

GT Kennedy, FS Azari, E Bernstein, B Nadeem… - Nature …, 2022 - nature.com
Suspicious nodules detected by radiography are often investigated by biopsy, but the
diagnostic yield of biopsies of small nodules is poor. Here we report a method—NIR-nCLE …

[HTML][HTML] Expert consensus on indocyanine green fluorescence imaging for thoracoscopic lung resection (The Version 2022)

F Cui, J Liu, M Du, J Fan, J Fu, Q Geng… - … lung cancer research, 2022 - ncbi.nlm.nih.gov
The use of the white-light thoracoscopy is hampered by the low contrast between oncologic
margins and surrounding normal parenchyma. As a result, many patients with in situ or …

New and effective EGFR-targeted fluorescence imaging technology for intraoperative rapid determination of lung cancer in freshly isolated tissue

C Li, J Mi, Y Wang, Z Zhang, X Guo, J Zhou… - European Journal of …, 2023 - Springer
Purpose During lung cancer surgery, it is very important to define tumor boundaries and
determine the surgical margin distance. In previous research, systemically application of …

Targeted detection of cancer cells during biopsy allows real-time diagnosis of pulmonary nodules

GT Kennedy, FS Azari, E Bernstein, B Nadeem… - European Journal of …, 2022 - Springer
Background The diagnostic yield of biopsies of solitary pulmonary nodules (SPNs) is low,
particularly in sub-solid lesions. We developed a method (NIR-nCLE) to achieve cellular …

Carcinoembryonic Antigen–Related Cell Adhesion Molecule Type 5 Receptor–Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer: A …

F Azari, RPJ Meijer, GT Kennedy, A Hanna… - JAMA network …, 2023 - jamanetwork.com
Importance Localization of subcentimeter ground glass opacities during minimally invasive
thoracoscopic lung cancer resections is a significant challenge in thoracic oncology …

Pafolacianine for intraoperative molecular imaging of cancer in the lung: The ELUCIDATE trial

IS Sarkaria, LW Martin, DC Rice, SH Blackmon… - The Journal of thoracic …, 2023 - Elsevier
Objective The study objective was to determine the clinical utility of pafolacianine, a folate
receptor–targeted fluorescent agent, in revealing by intraoperative molecular imaging folate …

Frozen section analysis in head and neck surgical pathology: A narrative review of the past, present, and future of intraoperative pathologic consultation

ML Urken, J Yun, MP Saturno, LA Greenberg, RL Chai… - Oral Oncology, 2023 - Elsevier
Frozen section has remained the diagnostic gold standard for intraoperative pathological
evaluation of surgical margins for head and neck specimens. While achieving tumor-free …