Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …

EcoCyc is a bioinformatics database available online at EcoCyc. org that describes the
genome and the biochemical machinery of Escherichia coli K-12 MG1655. The long-term …

Abstract The Reference Sequence (RefSeq) project at the National Center for Biotechnology
Information (NCBI) contains nearly 200 000 bacterial and archaeal genomes and 150 …

MetaCyc (MetaCyc. org) is a comprehensive reference database of metabolic pathways and
enzymes from all domains of life. It contains 2749 pathways derived from more than 60 000 …

The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …

EcoCyc (EcoCyc. org) is a freely accessible, comprehensive database that collects and
summarizes experimental data for Escherichia coli K-12, the best-studied bacterial model …

The last few decades have led to an explosion in our understanding of the major roles that
small regulatory RNAs (sRNAs) play in regulatory circuits and the responses to stress in …

Protein concentrations are set by a complex interplay between gene-specific regulatory
processes and systemic factors, including cell volume and shared gene expression …

INTRODUCTION The generation of biological data is presenting us with one of the most
demanding analysis challenges the world has ever faced, not only in terms of storage and …

Organisms determine the transcription rates of thousands of genes through a few modes of
regulation that recur across the genome. In bacteria, the relationship between the regulatory …