G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

For cancers to develop, sustain and spread, the appropriation of key homeostatic
physiological systems that influence cell growth, migration and death, as well as …

Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour
blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to …

The dense collagen network in tumors significantly reduces the penetration and efficacy of
nanotherapeutics. We tested whether losartan—a clinically approved angiotensin II receptor …

Recent epidemiological analyses suggest that incident cancer may be more common
among patients with preexisting heart failure (HF) than in patients without HF. Arguments …

The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …

Background Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor
blockers (ARBs) reduce cardiovascular disease (CVD) events, but a recent meta-analysis of …

Cancer is a set of extremely complex diseases, which are increasingly prominent today, as it
affects and kills millions of people worldwide, being the subject of intense study both in its …

Background Some oncogenes such as ERBB2 and EGFR are over-expressed in only a
subset of patients. Cancer outlier profile analysis is one of computational approaches to …

Background: Epidemiologic and biochemical evidence suggest a role of statins and
angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) as …