ABSTRACT C-Myc overexpression is a common finding in pancreatic cancer and predicts
the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby …

A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …

We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling,
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …

Combination therapies consisting of multiple short therapeutic RNAs, such as small
interfering RNA (siRNA) and microRNA (miRNA), have enormous potential in cancer …

Abstract MicroRNA-34 (miR-34) plays central roles in human diseases, especially cancers.
Inactivation of miR-34 is detected in cancer cell lines and tumor tissues versus normal …

Pancreatic cancer is one of the most aggressive tumors associated with a poor clinical
prognosis, weakly effective therapeutic options. Therefore, there is a strong impetus to …

Cathepsins are an important category of enzymes that have attracted great attention for the
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …

Background N6-methyladenosine (m6A) modification holds an important position in
tumorigenesis and metastasis because it can change gene expression and even function in …

Despite recent advancements in cancer therapies, challenges such as severe toxic effects,
non-selective targeting, resistance to chemotherapy and radiotherapy, and recurrence of …

Melanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the
brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis …