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Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa
Mammals co-exist with resident microbial ecosystem that is composed of an incredible
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …
Helminth infections and host immune regulation
Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …
regions. However, regions where helminth parasites are endemic record much lower …
A guide to histomorphological evaluation of intestinal inflammation in mouse models
U Erben, C Loddenkemper, K Doerfel… - … journal of clinical …, 2014 - pmc.ncbi.nlm.nih.gov
Histomorphology remains a powerful routine evaluating intestinal inflammation in animal
models. Emphasizing the focus of a given animal study, histopathology can overstate …
models. Emphasizing the focus of a given animal study, histopathology can overstate …
[HTML][HTML] GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
Tregs not only keep immune responses to autoantigens in check, but also restrain those
directed toward pathogens and the commensal microbiota. Control of peripheral immune …
directed toward pathogens and the commensal microbiota. Control of peripheral immune …
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven
inhibition of host immunity during chronic infection. We addressed whether parasites can …
inhibition of host immunity during chronic infection. We addressed whether parasites can …
Regulatory T‐cells in helminth infection: induction, function and therapeutic potential
Helminth parasites infect an alarmingly large proportion of the world's population, primarily
within tropical regions, and their ability to down‐modulate host immunity is key to their …
within tropical regions, and their ability to down‐modulate host immunity is key to their …
Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus
Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent
model of the immunology of gastrointestinal helminth infections of humans and livestock. It is …
model of the immunology of gastrointestinal helminth infections of humans and livestock. It is …
Immunity to helminths: resistance, regulation, and susceptibility to gastrointestinal nematodes
Helminth parasites are a highly successful group of pathogens that challenge the immune
system in a manner distinct from rapidly replicating infectious agents. Of this group …
system in a manner distinct from rapidly replicating infectious agents. Of this group …
[HTML][HTML] Susceptibility and immunity to helminth parasites
Parasitic helminth infection remains a global health problem, whilst the ability of worms to
manipulate and dampen the host immune system is attracting interest in the fields of allergy …
manipulate and dampen the host immune system is attracting interest in the fields of allergy …
The Many Functions of Foxp3+ Regulatory T Cells in the Intestine
Throughout the last years, gut-resident Foxp3+ regulatory T (Treg) cells have been
associated with a growing number of tissue-specific functions in the intestine, comprising …
associated with a growing number of tissue-specific functions in the intestine, comprising …