Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
Regulation of mTORC2 signaling
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master
regulator of cell growth and metabolism, forms two structurally and functionally distinct …
regulator of cell growth and metabolism, forms two structurally and functionally distinct …
Dissecting the contribution of host genetics and the microbiome in complex behaviors
The core symptoms of many neurological disorders have traditionally been thought to be
caused by genetic variants affecting brain development and function. However, the gut …
caused by genetic variants affecting brain development and function. However, the gut …
Targeted suppression of mTORC2 reduces seizures across models of epilepsy
Epilepsy is a neurological disorder that poses a major threat to public health.
Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network …
Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network …
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
ZX Xu, GH Kim, JW Tan, AE Riso, Y Sun, EY Xu… - Nature …, 2020 - nature.com
Mutations that inactivate negative translation regulators cause autism spectrum disorders
(ASD), which predominantly affect males and exhibit social interaction and communication …
(ASD), which predominantly affect males and exhibit social interaction and communication …
Microbiota and microglia interactions in ASD
M Davoli-Ferreira, CA Thomson, KD McCoy - Frontiers in immunology, 2021 - frontiersin.org
Autism spectrum disorders (ASD) are serious, highly variable neurodevelopmental
disorders, commonly characterized by the manifestation of specific behavioral abnormalities …
disorders, commonly characterized by the manifestation of specific behavioral abnormalities …
[HTML][HTML] Current approaches and future directions for the treatment of mTORopathies
The mechanistic target of rapamycin (mTOR) is a kinase at the center of an evolutionarily
conserved signaling pathway that orchestrates cell growth and metabolism. mTOR responds …
conserved signaling pathway that orchestrates cell growth and metabolism. mTOR responds …
Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a negative
regulator of AKT/mTOR signaling pathway. Mutations in PTEN are found in patients with …
regulator of AKT/mTOR signaling pathway. Mutations in PTEN are found in patients with …
The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
Brain somatic mutations in various components of the mTOR complex 1 (mTORC1) pathway
have emerged as major causes of focal malformations of cortical development and …
have emerged as major causes of focal malformations of cortical development and …