A comprehensive review of recent advances in the biological activities of quinazolines
HAM Gomaa - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Quinazoline heterocycles are critical in the development of medications. Quinazoline
derivatives have been intensively researched, providing a wide range of compounds with …
derivatives have been intensively researched, providing a wide range of compounds with …
Design and synthesis of new dihydropyrimidine derivatives with a cytotoxic effect as dual EGFR/VEGFR-2 inhibitors
We developed and synthesized tetrahydropyrimidine derivatives as possible cytotoxic
agents to inhibit EGFR and VEGFR-2 in the present study. Our study completely assesses …
agents to inhibit EGFR and VEGFR-2 in the present study. Our study completely assesses …
New s-Triazine/Tetrazole conjugates as potent antifungal and antibacterial agents: Design, molecular docking and mechanistic study
RA Mekheimer, GEDA Abuo-Rahma… - Journal of Molecular …, 2022 - Elsevier
A novel hybrid N 2-(tetrazol-5-yl)-6-substituted-5, 6-dihydro-1, 3, 5-triazine-2, 4-diamines
have been synthesized in excellent yields through one-pot multi-component reaction of 5 …
have been synthesized in excellent yields through one-pot multi-component reaction of 5 …
Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition
MM Amin, GEDA Abuo-Rahma, MSA Shaykoon… - Bioorganic …, 2023 - Elsevier
The present study established thirteen novel 8-hydroxyquinoline/chalcone hybrids 3a–m of
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …
Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4 (3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity
YM Khetmalis, A Fathima, M Schweipert… - International Journal of …, 2023 - mdpi.com
A series of novel quinazoline-4-(3H)-one derivatives were designed and synthesized as
histone deacetylase 6 (HDAC6) inhibitors based on novel quinazoline-4-(3H)-one as the …
histone deacetylase 6 (HDAC6) inhibitors based on novel quinazoline-4-(3H)-one as the …
Design, synthesis, and antiproliferative properties of new 1, 2, 3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors
A new series of substituted aryl carboximidamide VIa-o was designed and synthesised. IR, 1
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
New series of 4, 6-diaryl pyrimidines: facile synthesis and antiproliferative activity as dual EGFR/VEGFR-2 inhibitors
YA Mostafa, JA Assoud, AY Desoky… - Frontiers in …, 2024 - frontiersin.org
Introduction We developed and produced a new series of 4, 6-diaryl-pyrimidines 9–29 as
antiproliferative agents targeting EGFR/VEGFR-2. Methods The antiproliferative efficacy of …
antiproliferative agents targeting EGFR/VEGFR-2. Methods The antiproliferative efficacy of …
Design, synthesis, molecular modeling, and anticancer evaluation of new VEGFR-2 inhibitors based on the indolin-2-One scaffold
A new series of indoline-2-one derivatives was designed and synthesized based on the
essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were …
essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were …
Introducing Fe3O4@ SiO2@ KCC-1@ MPTMS@ CuII catalytic applications for the green one-pot syntheses of 2-aryl (or heteroaryl)-2, 3-dihydroquinazolin-4 (1H) …
MH Galehban, B Zeynizadeh, H Mousavi - Journal of Molecular Structure, 2023 - Elsevier
In this study, the new catalytic applications of the dendritic Fe 3 O 4@ SiO 2@ KCC-1@
MPTMS@ Cu II mesoporous nanocomposite have been introduced for the green one-pot …
MPTMS@ Cu II mesoporous nanocomposite have been introduced for the green one-pot …
Design, synthesis, and antiproliferative activity of new 5-chloro-indole-2-carboxylate and pyrrolo [3, 4-b] indol-3-one derivatives as potent inhibitors of egfrt790m …
LH Al-Wahaibi, AF Mohammed, MH Abdelrahman… - Molecules, 2023 - mdpi.com
Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of
anticancer drugs since they are over-activated in several malignancies. We present here the …
anticancer drugs since they are over-activated in several malignancies. We present here the …