A review of high shear wet granulation for better process understanding, control and product development
B Liu, J Wang, J Zeng, L Zhao, Y Wang, Y Feng… - Powder Technology, 2021 - Elsevier
High shear wet granulation (HSWG) is considered a complicated and multivariate
pharmaceutical process that is influenced by a large number of variables derived from …
pharmaceutical process that is influenced by a large number of variables derived from …
Manufacture and characterization of carbonated lightweight aggregates from waste paper fly ash
The combustion of biomass and waste paper sludge in a fluidized bed is ecologically
profitable. However, a large amount of by-product with high hydraulic reactivity is produced …
profitable. However, a large amount of by-product with high hydraulic reactivity is produced …
[HTML][HTML] Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis
The current study was to understand how process variables of high shear wet granulations
affect physical properties of granules and tablets. The knowledge gained was intended to be …
affect physical properties of granules and tablets. The knowledge gained was intended to be …
Comprehensive study of intermediate and critical quality attributes for process control of high-shear wet granulation using multivariate analysis and the quality by …
A robust manufacturing process and the relationship between intermediate quality attributes
(IQAs), critical quality attributes (CQAs), and critical process parameters (CPPs) for high …
(IQAs), critical quality attributes (CQAs), and critical process parameters (CPPs) for high …
High shear wet granulation: Improved understanding of the effects of process variables on granule and tablet properties of a high-dose, high-hydrophobicity API based …
B Liu, J Wang, Q Zhou, L Zhao, Y Wang, L Shen… - Advanced Powder …, 2022 - Elsevier
High shear wet granulation (HSWG), as a widely used granulation technology, has been
studied extensively. However, for the HSWG of formulations containing hydrophobic …
studied extensively. However, for the HSWG of formulations containing hydrophobic …
New gentle-wing high-shear granulator: Impact of processing variables on granules and tablets characteristics of high-drug loading formulation using design of …
The aim of this work was to study the application of design of experiment (DoE) approach in
defining design space for granulation and tableting processes using a novel gentle-wing …
defining design space for granulation and tableting processes using a novel gentle-wing …
Granulation processing parameters on the mechanical properties of diatomite-based porous granulates
Y Liu, D Scharf, T Graule, FJ Clemens - Powder technology, 2014 - Elsevier
The development of cheap natural porous diatomite into catalyst supporting materials has
obvious technical interests. High-intensity granulation process in the presence of clay-based …
obvious technical interests. High-intensity granulation process in the presence of clay-based …
Effects of process and design parameters on granule size distribution in a continuous high shear granulation process
Purpose Wet granulation is widely used in the pharmaceutical industry. This advantageous
technology is capable of enhancing compression and powder handling, decreasing …
technology is capable of enhancing compression and powder handling, decreasing …
Comparison of quality parameters of granola produced by wet granulation with commercially available product
This study involves comparing key quality parameters (size, textural) of commercially
available breakfast cereal granola with product produced by high shear and fluidised bed …
available breakfast cereal granola with product produced by high shear and fluidised bed …
[PDF][PDF] High-shear granulation process: Influence of processing parameters on critical quality attributes of acetaminophen granules and tablets using design of …
Application of quality by design (QbD) in high shear granulation process is critical and need
to recognize the correlation between the granulation process parameters and the properties …
to recognize the correlation between the granulation process parameters and the properties …