A review of high shear wet granulation for better process understanding, control and product development

B Liu, J Wang, J Zeng, L Zhao, Y Wang, Y Feng… - Powder Technology, 2021 - Elsevier
High shear wet granulation (HSWG) is considered a complicated and multivariate
pharmaceutical process that is influenced by a large number of variables derived from …

Manufacture and characterization of carbonated lightweight aggregates from waste paper fly ash

B Bouzar, Y Mamindy-Pajany - Powder Technology, 2022 - Elsevier
The combustion of biomass and waste paper sludge in a fluidized bed is ecologically
profitable. However, a large amount of by-product with high hydraulic reactivity is produced …

[HTML][HTML] Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis

P Thapa, DH Choi, MS Kim, SH Jeong - Asian Journal of Pharmaceutical …, 2019 - Elsevier
The current study was to understand how process variables of high shear wet granulations
affect physical properties of granules and tablets. The knowledge gained was intended to be …

Comprehensive study of intermediate and critical quality attributes for process control of high-shear wet granulation using multivariate analysis and the quality by …

JK Han, BS Shin, DH Choi - Pharmaceutics, 2019 - mdpi.com
A robust manufacturing process and the relationship between intermediate quality attributes
(IQAs), critical quality attributes (CQAs), and critical process parameters (CPPs) for high …

High shear wet granulation: Improved understanding of the effects of process variables on granule and tablet properties of a high-dose, high-hydrophobicity API based …

B Liu, J Wang, Q Zhou, L Zhao, Y Wang, L Shen… - Advanced Powder …, 2022 - Elsevier
High shear wet granulation (HSWG), as a widely used granulation technology, has been
studied extensively. However, for the HSWG of formulations containing hydrophobic …

New gentle-wing high-shear granulator: Impact of processing variables on granules and tablets characteristics of high-drug loading formulation using design of …

MH Fayed, SI Abdel-Rahman, FK Alanazi… - Drug Development …, 2017 - Taylor & Francis
The aim of this work was to study the application of design of experiment (DoE) approach in
defining design space for granulation and tableting processes using a novel gentle-wing …

Granulation processing parameters on the mechanical properties of diatomite-based porous granulates

Y Liu, D Scharf, T Graule, FJ Clemens - Powder technology, 2014 - Elsevier
The development of cheap natural porous diatomite into catalyst supporting materials has
obvious technical interests. High-intensity granulation process in the presence of clay-based …

Effects of process and design parameters on granule size distribution in a continuous high shear granulation process

W Meng, S Oka, X Liu, T Omer… - Journal of …, 2017 - Springer
Purpose Wet granulation is widely used in the pharmaceutical industry. This advantageous
technology is capable of enhancing compression and powder handling, decreasing …

Comparison of quality parameters of granola produced by wet granulation with commercially available product

PB Pathare, N Baş, EP Byrne - Food and bioproducts processing, 2012 - Elsevier
This study involves comparing key quality parameters (size, textural) of commercially
available breakfast cereal granola with product produced by high shear and fluidised bed …

[PDF][PDF] High-shear granulation process: Influence of processing parameters on critical quality attributes of acetaminophen granules and tablets using design of …

MH Fayed, SI Abdel-Rahman, FK Alanazi… - Acta poloniae …, 2017 - ptfarm.pl
Application of quality by design (QbD) in high shear granulation process is critical and need
to recognize the correlation between the granulation process parameters and the properties …