JAK inhibitors in solid organ transplantation

S Assadiasl, H Mojtahedi… - The Journal of Clinical …, 2023‏ - Wiley Online Library
Janus kinase (JAK) inhibitors are a novel group of immunosuppressive drugs approved to
treat certain rheumatic and allergic disorders; however, their efficacy in the regulation of …

[HTML][HTML] Graft-versus-host disease following liver transplantation: A systematic review of literature

F Kneifel, T Vogel, E Bormann, F Becker… - Hepatology …, 2023‏ - journals.lww.com
Background: Graft-versus-host disease following liver transplantation is a serious and
usually fatal complication. Data identifying the risk factors and specifying the diagnosis and …

How I diagnose and treat acute graft-versus-host disease after solid organ transplantation

JP Cooper, JL Abkowitz - Blood, 2023‏ - ashpublications.org
Acute graft-versus-host disease (GVHD) is a rare complication after solid organ
transplantation (SOT) that carries high mortality. Caused by immunocompetent donor …

[HTML][HTML] Graft-versus-host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations

LF Newell, J Dunlap, K Gatter, GC Bagby… - American Journal of …, 2021‏ - Elsevier
Graft-versus-host disease after liver transplantation (LT-GVHD) is rare, frequently fatal, and
associated with bone marrow failure (BMF), cytopenias, and hyperferritinemia. Given …

Ruxolitinib Pharmacokinetics and Pharmacodynamics in Children with Acute and Chronic Graft-versus-Host Disease

E Cook, M Dong, SCC Chiang, D Luedeke… - … and cellular therapy, 2024‏ - Elsevier
We evaluated the pharmacokinetics (PK) of oral ruxolitinib in children with steroid-refractory
acute graft-versus-host disease (aGVHD)(age< 12 years) and chronic GVHD …

Current advances in graft-versus-host disease after intestinal transplantation

K Oza, J Kang, D Patil, KL Owen, W Cui, K Khan… - …, 2024‏ - journals.lww.com
Graft-versus-host disease (GvHD) remains a potentially fatal complication following
intestinal transplant (ITx). Over the past decade, advances in the understanding of the …

Donor‐targeted serotherapy as a rescue therapy for steroid‐resistant acute GVHD after HLA‐mismatched kidney transplantation

J Zuber, O Boyer, B Neven, I Jollet… - American Journal of …, 2020‏ - Wiley Online Library
Acute graft‐versus‐host disease (GVHD) is a rare but frequently lethal complication after
solid organ transplantation. GVHD occurs in unduly immunocompromised hosts but requires …

Treatment of Late-onset Acute Graft-versus-host Disease Following Double Lung Transplantation Using a JAK2 Inhibitor

R Alyamany, A Alnughmush, F Albaiz, M Aversa… - …, 2024‏ - journals.lww.com
Acute graft-versus-host disease (aGVHD) is a rare but potentially life-threatening
complication that can occur after solid organ transplantation, particularly in organs with …

Can donor-derived cell-free DNA detect graft-versus-host disease in solid organ transplantation: a case report

MD Williams, J Thomas, A Paner, EY Chan… - Transplantation …, 2022‏ - Elsevier
Graft-versus-host disease (GVHD) is a rare complication after solid organ transplant. We
present a case of GVHD after simultaneous pancreas kidney transplant. The patient was …

A 14-year follow-up of a combined liver-pancreas-kidney transplantation: Case report and literature review

G Zhang, W Qin, J Yuan, C Ming, S Yue, Z Liu… - Frontiers in …, 2020‏ - frontiersin.org
Objective: To investigate the long-term effect of triple organ transplantation (liver, kidney,
and pancreas) in a patient with end-stage liver disease, post chronic hepatitis B, cirrhosis …