Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …

The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord
injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a …

Fibrotic scar tissue formation occurs in humans and mice. The fibrotic scar impairs tissue
regeneration and functional recovery. However, the origin of scar-forming fibroblasts is …

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could
support or augment recovery. Targeting these cells requires a clearer understanding of their …

Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Wound repair is a complex and dynamic process, involving stages of hemostasis,
inflammation, proliferation, and remodeling. Standard methods currently used for clinical …