Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …

Patients with diabetes mellitus have> 2× the risk for develo** heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Background Patients with ischemic stroke or transient ischemic attack (TIA) are at increased
risk for future cardiovascular events despite current preventive therapies. The identification …

Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

Elevated levels of diastolic BP and especially systolic BP (SBP) are major risk factors for the
development of HF. 18, 19 One of the most impactful observations from the Framingham …

Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …

Type 2 diabetes individuals are at high risk for macrovascular complications: myocardial
infarction, stroke and cardiovascular mortality. Recent cardiovascular outcome trials have …

Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …

Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …