The dynamic behaviour of epithelial cell sheets plays a central role during development,
growth, disease and wound healing. These processes occur as a result of cell adhesion …

The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …

This monograph presents a general mathematical theory for biological growth. It provides
both a conceptual and a technical foundation for the understanding and analysis of …

We introduce an Active Vertex Model (AVM) for cell-resolution studies of the mechanics of
confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail …

In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …

The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …

Epithelia are sheets of cells that are dynamically remodelled by cell division and cell death
during development. Here we describe the cell shapes and packings as networks of …

Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and
response to treatment of different cancer cell lines. Their popularity is largely due to the …

Embryonic epithelia achieve complex morphogenetic movements, including in-plane
resha**, bending and folding, through the coordinated action and rearrangement of …