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Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention
SS Hecht, DK Hatsukami - Nature Reviews Cancer, 2022 - nature.com
Tobacco products present a deadly combination of nicotine addiction and carcinogen
exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless …
exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless …
Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: a review
Smoking is a serious global health issue. Cigarette smoking contains over 7000 different
chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons …
chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons …
[HTML][HTML] Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
From cultivation to cancer: formation of N-nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications
SB Stanfill, SS Hecht, AC Joerger… - Critical reviews in …, 2023 - Taylor & Francis
Tobacco use is a major cause of preventable morbidity and mortality globally. Tobacco
products, including smokeless tobacco (ST), generally contain tobacco-specific N …
products, including smokeless tobacco (ST), generally contain tobacco-specific N …
Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism
The International Agency for Research on Cancer has classified the tobacco-specific
nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
Pivotal Role of Mass Spectrometry for the Assessment of Exposure to Reactive Chemical Contaminants: From the Exposome to the Adductome
L Debrauwer, L Mervant, O Laprevote… - Mass Spectrometry …, 2024 - Wiley Online Library
ABSTRACT A large part of the Human chemical exposome is now well characterized, and its
health effects has been widely documented, although precise causal links remain difficult to …
health effects has been widely documented, although precise causal links remain difficult to …
Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK
M Korenjak, NA Temiz, S Keita, B Chavanel, C Renard… - bioRxiv, 2024 - biorxiv.org
Tobacco usage is linked to multiple cancer types and accounts for a quarter of all cancer-
related deaths. Tobacco smoke contains various carcinogenic compounds, including …
related deaths. Tobacco smoke contains various carcinogenic compounds, including …
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat
The tobacco-specific nitrosamine N′-nitrosonornicotine (NNN) and its close analogue 4-(N-
nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) are classified as “carcinogenic to …
nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) are classified as “carcinogenic to …
Mass Spectrometric Quantitation of N′-Nitrosonornicotine-1N-oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users
Y Li, SS Hecht - Chemical research in toxicology, 2022 - ACS Publications
N′-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK),
which always occur together and are present exclusively in tobacco products, are classified …
which always occur together and are present exclusively in tobacco products, are classified …
Structure Elucidation and Quantitation of 11 N′-n-Acylnornicotines in Cherry-Red Tobacco
Y Li, T Pang, J Shi, G Bai, X Sui… - Journal of …, 2023 - academic.oup.com
Eleven consecutive N′-n-acylnornicotines from cherry-red tobacco were structurally
elucidated and quantitively analyzed using chromatography and mass spectrometry. All of …
elucidated and quantitively analyzed using chromatography and mass spectrometry. All of …