Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
Risk factors for type 2 diabetes mellitus: an exposure-wide umbrella review of meta-analyses
Background Type 2 diabetes mellitus (T2DM) is a global epidemic associated with
increased health expenditure, and low quality of life. Many non-genetic risk factors have …
increased health expenditure, and low quality of life. Many non-genetic risk factors have …
The MR-Base platform supports systematic causal inference across the human phenome
Results from genome-wide association studies (GWAS) can be used to infer causal
relationships between phenotypes, using a strategy known as 2-sample Mendelian …
relationships between phenotypes, using a strategy known as 2-sample Mendelian …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
Bias due to participant overlap in two‐sample Mendelian randomization
Mendelian randomization analyses are often performed using summarized data. The causal
estimate from a one‐sample analysis (in which data are taken from a single data source) …
estimate from a one‐sample analysis (in which data are taken from a single data source) …
New genetic loci link adipose and insulin biology to body fat distribution
D Shungin, TW Winkler, DC Croteau-Chonka… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
outcomes, independent of overall adiposity. To increase our understanding of the genetic …
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …
obesity better, here we conduct a genome-wide association study and Metabochip meta …
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic
health. To date, most genetic studies of glycemic traits have focused on individuals of …
health. To date, most genetic studies of glycemic traits have focused on individuals of …
The UK10K project identifies rare variants in health and disease
Statistics group Ciampi Antonio 8 Greenwood Celia MT … - Nature, 2015 - nature.com
The contribution of rare and low-frequency variants to human traits is largely unexplored.
Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes …
Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes …