Transcription is regulated by transcription factor (TF) binding at promoters and distal
regulatory elements and histone modifications that control the accessibility of these …

Early responses to invading pathogens and to non-microbial danger signals are mediated
by different innate immune and parenchymal tissue cells, which are able to respond to a …

Stem-cell-derived tissues could transform disease research and therapy, yet most methods
generate functionally immature products. We investigate how human pluripotent stem cells …

Transcriptional regulatory networks (TRNs) provide insight into cellular behavior by
describing interactions between transcription factors (TFs) and their gene targets. The assay …

Lipopolysaccharide (LPS) can induce systemic inflammatory response (SIR) in animals.
Understanding the regulatory mechanism of SIR and therapies to ensure healthy growth is …

Methylmalonic aciduria (MMA) is an inborn error of metabolism with multiple monogenic
causes and a poorly understood pathogenesis, leading to the absence of effective causal …

Glioblastoma (GBM) is defined by heterogeneous and resilient cell populations that closely
reflect neurodevelopmental cell types. Although it is clear that GBM echoes early and …

Injury to the nervous system triggers a multicellular response in which epigenetic
mechanisms play an important role in regulating cell type-specific transcriptional changes …

ABSTRACT Introduction Systemic Lupus Erythematosus (SLE) is a multi-dimensional
autoimmune disease involving numerous tissues throughout the body. The chromatin …

Axon regeneration in the central nervous system is prevented in part by a developmental
decline in the intrinsic regenerative ability of maturing neurons. This loss of axon growth …