[HTML][HTML] Recent developments in the high-throughput separation of biologically active chiral compounds via high performance liquid chromatography

C De Luca, S Felletti, FA Franchina, D Bozza… - … of Pharmaceutical and …, 2024 - Elsevier
Bioactive compounds, including active pharmaceutical ingredients (APIs), are often chiral
molecules where stereoisomers have different biological and therapeutic activity …

[HTML][HTML] Dimethyl carbonate as a green alternative to acetonitrile in reversed-phase liquid chromatography. Part I: Separation of small molecules

S Felletti, M Spedicato, D Bozza, C De Luca… - … of Chromatography A, 2023 - Elsevier
Nowadays, environmental problems are drawing the attention of governments and
international organisations, which are therefore encouraging the transition to green …

Chiral Separation of Cannabichromene, Cannabicyclol, and Their Acidic Analogs on Polysaccharide Chiral Stationary Phases

JM Ferraro, WJ Umstead - Molecules, 2023 - mdpi.com
Until recently, chirality has not been a major focus in the study of cannabinoids, as most
cannabinoids of interest, such as cannabidiol and tetrahydrocannabinol, exist as a single …

[HTML][HTML] Green cannabigerol purification through simulated moving bed chromatography

C De Luca, Y Krauke, S Stephan, G Greco… - Green Analytical …, 2023 - Elsevier
Cannabigerol (CBG) is a minor cannabinoid present in Cannabis sativa L. This molecule is
gaining increasing popularity thanks to its antibacterial, antimicrobial, antidepressant and …

Progress in the analysis of phytocannabinoids by HPLC and UPLC (or UHPLC) during 2020–2023

L Nahar, P Chaiwut, S Sangthong… - Phytochemical …, 2024 - Wiley Online Library
Introduction Organic molecules that bind to cannabinoid receptors are known as
cannabinoids. These molecules possess pharmacological properties similar to those …

[HTML][HTML] Enantioseparation of chiral phytocannabinoids in medicinal cannabis

F Russo, F Tolomeo, MA Vandelli, G Biagini… - … of Chromatography B, 2023 - Elsevier
The evaluation of the chiral composition of phytocannabinoids in the cannabis plant is
particularly important as the pharmacological effects of the (+) and (-) enantiomers of these …

Bidimensional heart-cut achiral-chiral liquid chromatography coupled to high-resolution mass spectrometry for the separation of the main chiral phytocannabinoids …

F Russo, E Ferri, D Pinetti, MA Vandelli, A Laganà… - Talanta, 2024 - Elsevier
In this work, a heart-cut bidimensional achiral-chiral liquid chromatography method coupled
to high-resolution mass spectrometry was developed for the separation of the main …

Structured microgroove columns as a potential solution to obtain perfectly ordered particle beds

B Vankeerberghen, S Verloy, ISM Jimidar… - … of Chromatography A, 2023 - Elsevier
We report on a novel concept to produce ordered beds of spherical particles in a suitable
format for liquid chromatography. In this concept, spherical particles are either positioned …

Determination of Δ9-THC, THCA, Δ8-THC, and total Δ9-THC in 53 smokable hemp plant products by liquid chromatography and photodiode array detection

WB Wilson, AA Urbas, M Abdur-Rahman, A Romares… - Forensic Chemistry, 2024 - Elsevier
The passage of the 2018 Farm Bill defined hemp as cannabis plant containing 0.3% or less
of Δ 9-THC, which led to a large increase in hemp production in the United States in 2021 …

A Reverse Thinking Based on Partially Methylated Aldononitrile Acetates to Analyze Glycoside Linkages of Polysaccharides Using Liquid Chromatography–Multiple …

JN Gao, Y Li, J Liang, L **ao, HX Kuang… - Journal of Agricultural …, 2024 - ACS Publications
Glycoside linkage analyses of medicine and food homologous plant polysaccharides have
always been a key point and a difficulty of structural characterization. The gas …