Malaria: an overview

M Fikadu, E Ashenafi - Infection and Drug Resistance, 2023 - Taylor & Francis
Malaria is a global public health burden with an estimated 229 million cases reported
worldwide in 2019. About 94% of the reported cases were recorded in the African region …

[HTML][HTML] The role of ferroptosis in metabolic diseases

L **e, B Fang, C Zhang - Biochimica et Biophysica Acta (BBA)-molecular …, 2023 - Elsevier
The annual incidence of metabolic diseases such as diabetes, non-alcoholic fatty liver
disease (NAFLD), osteoporosis, and atherosclerosis (AS) is increasing, resulting in a heavy …

Molecular docking, simulation and binding free energy analysis of small molecules as PfHT1 inhibitors

AJ Owoloye, FC Ligali, OA Enejoh, AZ Musa, O Aina… - PloS one, 2022 - journals.plos.org
Antimalarial drug resistance has thrown a spanner in the works of malaria elimination. New
drugs are required for ancillary support of existing malaria control efforts. Plasmodium …

Nano‐sized Co (II), Ni (II), and Zr (IV) complexes of quinaldine‐based azo dye for promising therapeutic and catalytic applications: Synthesis, characterization, density …

AM Khedr, M Gaber, M Elsharkawy… - Applied …, 2023 - Wiley Online Library
Novel azo dye containing the heterocyclic quinaldine nucleus, 3‐((2‐methylquinolin‐4‐yl)
diazenyl) naphthalen‐2‐ol HL, and its Co (II), Ni (II) and Zr (IV) nano‐sized metal chelates …

Expansion Microscopy Reveals Plasmodium falciparum Blood-Stage Parasites Undergo Anaphase with A Chromatin Bridge in the Absence of Mini-Chromosome …

B Liffner, S Absalon - Microorganisms, 2021 - mdpi.com
The malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within
an intact nuclear envelope, and differs significantly from its human host. Mitosis is …

Malaria therapeutics: are we close enough?

H Tripathi, P Bhalerao, S Singh, H Arya, BS Alotaibi… - Parasites & vectors, 2023 - Springer
Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

Basic nitrogen (BaN) is a key property of antimalarial chemical space

H Valluri, A Bhanot, S Shah, N Bhandaru… - Journal of Medicinal …, 2023 - ACS Publications
Most antimalarials are based on basic N-heterocycles and possess amine functionalities.
Despite this, the role of basic nitrogen (BaN) in antimalarial drug design has not been …

Drug development strategies for malaria: With the hope for new antimalarial drug discovery—an update

SK Pandey, U Anand, WA Siddiqui… - Advances in …, 2023 - Wiley Online Library
Malaria continued to be a deadly situation for the people of tropical and subtropical
countries. Although there has been a marked reduction in new cases as well as mortality …

Prospects of halofuginone as an antiprotozoal drug scaffold

J Gill, A Sharma - Drug discovery today, 2022 - Elsevier
Highlights•The global prevalence of parasitic protozoan diseases remains a significant
public health challenge.•Halofuginone, a plant-derived compound, has beneficial roles in …

Recent developments in antimalarial drug discovery

T Umumararungu, JB Nkuranga, G Habarurema… - Bioorganic & Medicinal …, 2023 - Elsevier
Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …